Endocrine Abstracts

Physiological role of acylated ghrelin (AG), unacylated ghrelin (UAG) and obestatin is poorly understood especially in childhood. To understand their biological implications in obesity and metabolic syndrome (MS), we measured AG, UAG, obestatin, at fasting and every 60′ during oral glucose tolerance test (OGTT) in 60 prepubertal (PP–OB; 32) and pubertal (P-OB; 28) children. Paediatric IDF 2007 criteria was used to identifying MS. In PP-OB group, 20 (62.5%) children ...

Introduction: Generously supported by IPSEN)-->In children, GH secretion is considered sufficient when at least one value is >20 ng/ml at the GHRH + arginine (ARG) test. Because GH typically peaks at 45 min, we evaluated whether peak occurrence at one specific time is predictive of clinical outcomes in short stature children who are GH sufficient.Subjects and methods: Children who performed a GHRH plus ARG ...

Background: Variations in gut microbiota might impact metabolic functions like caloric intake and energy expenditure leading to body weight excess. Microbiota modulation may be a potential approach for obesity management, especially in subject characterized by specific microbial enterotypes.Objective: We aimed to assess the impact of probiotic treatment in obese children and adolescents, under diet control, on weight loss, glucose, and insulin homeostasi...